Key result
Pretreatment with Ginkgo biloba extract 761 effectively alleviated doxorubicin-induced impaired spermatogenesis, oxidative stress, and apoptosis in rat testes.
Why the study?
Does Ginkgo biloba extract 761 (EGb) prevent doxorubicin-induced oxidative and apoptotic testicular toxicity in Sprague-Dawley male rats?
Population
Sprague-Dawley male rats (8 weeks old)
Comparison
Ginkgo biloba extract 761 5 mg kg every 2 days… vs Vehicle, doxorubicin alone (3 mg kg every 2 days…
Design
Preclinical
Follow-up
7 days after the first drug treatment
Authors
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May support preclinical testing of EGb761 against doxorubicin testicular toxicity; leaves open any human fertility application.
Does Ginkgo biloba extract 761 (EGb) prevent doxorubicin-induced oxidative and apoptotic testicular toxicity in Sprague-Dawley male rats?
Ginkgo biloba extract 761 protects against doxorubicin-induced oxidative stress and apoptosis in rat testes, suggesting potential as an adjuvant therapy to ameliorate testicular toxicity.
Wang et al. (2008) studied Doxorubicin-induced testicular toxicity. Ginkgo biloba extract 761 (EGb) vs. doxorubicin alone was evaluated on oxidative and apoptotic testicular toxicity. Pretreatment with Ginkgo biloba extract 761 effectively alleviated doxorubicin-induced impaired spermatogenesis, oxidative stress, and apoptosis in rat testes.
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