Why the study?
Does Ginkgo biloba extract 761 reduce doxorubicin-induced apoptotic damage in rat hearts and neonatal cardiomyocytes?
Population
Primary cultured neonatal rat cardiomyocytes and rats exposed to doxorubicin
Comparison
Ginkgo biloba extract 761 vs Vehicle or doxorubicin alone
Design
Preclinical
Follow-up
24 hours in vitro; 7 and 28 days in vivo
Authors
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Hypothesis-generating for EGb761 cardioprotection in doxorubicin regimens; leaves open translation to human trials and practice change.
Does Ginkgo biloba extract 761 reduce doxorubicin-induced apoptotic damage in rat hearts and neonatal cardiomyocytes?
Ginkgo biloba extract 761 counteracts doxorubicin-induced apoptotic damage in rat cardiomyocytes and hearts, suggesting potential cardioprotective effects against doxorubicin toxicity.
Liu et al. (2008) studied this question.
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