Why the study?
Does FR 7534 reduce myocardial infarct size in a canine model of ischemia and reperfusion?
Population
Anesthetized dogs with myocardial infarction produced by a 2-hour occlusion and reperfusion of the distal…
Comparison
FR 7534, administered with or without constant… vs Control dogs (no FR 7534)
Design
Preclinical
Follow-up
2-hour occlusion and reperfusion
Authors
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Should not change clinical practice; hypothesis-generating for calcium antagonists in reperfusion injury.
Does FR 7534 reduce myocardial infarct size in a canine model of ischemia and reperfusion?
The calcium antagonist FR 7534 significantly reduces myocardial infarct size in a canine ischemia-reperfusion model.
Meils et al. (2008) studied this question.
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