Key result
FR 34235 increased collateral perfusion to the subepicardium, midmyocardium, and subendocardium, demonstrating a more favorable effect on transmural blood flow distribution than nifedipine.
Why the study?
Does FR 34235 improve coronary collateral blood flow compared to nifedipine in anesthetized dogs with acute LAD ligation?
Population
Anesthetized dogs following acute ligation of the left anterior descending coronary artery
Comparison
FR 34235 infusion vs Nifedipine infusion
Design
Preclinical
Authors
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Hypothesis-generating in canine ischemia; leaves open any human translation or superiority over nifedipine.
Does FR 34235 improve coronary collateral blood flow compared to nifedipine in anesthetized dogs with acute LAD ligation?
In a canine model of acute ischemia, FR 34235 provided a more favorable transmural distribution of collateral blood flow than nifedipine when hypotension was minimized.
Gross et al. (1984) studied Acute myocardial ischemia. FR 34235 vs. Nifedipine was evaluated on True coronary collateral blood flow. FR 34235 increased collateral perfusion to the subepicardium, midmyocardium, and subendocardium, demonstrating a more favorable effect on transmural blood flow distribution than nifedipine.
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