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June 12, 2007Journal of Clinical OncologyOpen Access

Improved Overall Survival in Postmenopausal Women With Early Breast Cancer After Anastrozole Initiated After Treatment With Tamoxifen Compared With Continued Tamoxifen: The ARNO 95 Study

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Authors

MKManfred KaufmannWJW. JonatJHJ. Hilfrich

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Overview

Randomized trial demonstrates improved overall survival in postmenopausal women switching to anastrozole after tamoxifen, suggesting a more effective treatment approach.

Key Points

  • This study aims to evaluate whether switching from tamoxifen to anastrozole improves survival outcomes in postmenopausal women with early breast cancer.
  • Randomized, open-label study with 979 postmenopausal women after 2 years of tamoxifen treatment.
  • Patients received either anastrozole (1 mg/d) or continued tamoxifen (20 or 30 mg/d) for an additional 3 years.
  • Primary outcome was disease-free survival and secondary outcomes included overall survival and safety assessment.
  • Switching to anastrozole reduced disease recurrence risk (HR, 0.66; 95% CI, 0.44 to 1.00; P = .049).
  • Improved overall survival was observed with anastrozole (HR, 0.53; 95% CI, 0.28 to 0.99; P = .045).
  • Serious adverse events were lower in the anastrozole group (22.7%) compared to tamoxifen (30.8%).

Cite This Study

Kaufmann et al. (2007) studied this question.

synapsesocial.com/papers/6a711bbb660549caf2c5bdffhttps://doi.org/10.1200/jco.2006.08.8054
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Switching to Anastrozole Versus Continued Tamoxifen Treatment of Early Breast Cancer: Preliminary Results of the Italian Tamoxifen Anastrozole Trial2005 · 449 citations
  2. 2Hormone Replacement Therapy and Decreased Lung Cancer Survival2005 · 23 citations
  3. 3Switching to anastrozole (ANA) vs continued tamoxifen (TAM) treatment of early breast cancer (EBC). Updated results of the Italian tamoxifen anastrozole (ITA) trial2005 · 100 citations
  4. 4Mechanisms of tamoxifen resistance2004 · 660 citations
  5. 5A Comparison of Letrozole and Tamoxifen in Postmenopausal Women with Early Breast Cancer2005 · 1,587 citations