Why the study?
Does transcatheter intrapericardial tPA instillation improve drainage in a patient with post-operative pericardial effusion complicated by fibrinous adherence and thrombus?
Does transcatheter intrapericardial tPA instillation improve drainage in a patient with post-operative pericardial effusion complicated by fibrinous adherence and thrombus?
Intrapericardial instillation of tPA may be an effective strategy to dissolve fibrinous adhesions and thrombi to facilitate drainage of complex pericardial effusions.
On the 43rd day after open heart surgery, pericardial effusion developed in a patient and resulted in cardiac tamponade. Since the drainage could not be obtained by subxiphoid window technique due to location of fluid and presence of fibrinous adherence and a thrombus in pericardial space, transcatheter intrapericardial recombinant tissue plasminogen activator (tPA) was instilled in the patient. Thus, the intrapericardial fibrinous adherence and the thrombus disappeared, and the effusion was drained efficiently.
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Rahman et al. (1998) studied this question.
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