JoUmAL 1067 to stimuli of many kinds.Other toxins seem to block pro- cesses concerned in the transmission of co-ordinating stimuli between groups of cells.This appears to be the case with the tetanus and botulinum toxins, which interfere seriously with the acetylcholine mechanism (Ambache et al., 1948a(Ambache et al., , 1948b;;Burgen et al., 1949).In other instances, especially with the endotoxins now being disentangled from Gram- negative bacteria, cellular metabolic functions seem to be the foci of attack, but there is an appalling lack of information about these matters.Clearly we are on the threshold of a vast new world of cellular research from which we may gain rich treasure if we explore it critically and with imagination.The reward will include, I feel sure, progress not only in fundamental knowledge about life but in applied pathology, carrying with it new ideas about the recognition and treatment of disease no less than the forestalling of sickness.
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Evans et al. (1954) studied this question.
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