January 1, 2017BioMed Research InternationalOpen Access

Obesity Induces Artery-Specific Alterations: Evaluation of Vascular Function and Inflammatory and Smooth Muscle Phenotypic Markers

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Population

C57Bl/6 mice

Comparison

16-week high-fat diet to induce obesity vs Standard diet / non-obese controls (implied)

Design

Preclinical

Follow-up

16 weeks

Authors

ASAntónio G. SoaresUniversity of Hawaiʻi at Mānoa MCMaria Helena Catelli de CarvalhoUniversidade de São Paulo EAEliana Hiromi AkamineInstitute of Biomedical Science

Discussion

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Implication

Obesity impairs smooth muscle more in mesenteric than aortic arteries; leaves open artery-specific mechanisms for clinical translation.

Structured PICO

Population

C57Bl/6 mice

Intervention

16-week high-fat diet to induce obesity

Comparator

Standard diet / non-obese controls (implied)

Outcome

Vascular reactivity, mRNA expression of inflammatory and smooth muscle phenotypic markers, and collagen deposition in small mesenteric arteries (SMA) and thoracic aorta (TA)surrogate

Obesity induces artery-specific vascular alterations in mice, with greater smooth muscle impairment and collagen deposition in small mesenteric arteries compared to the thoracic aorta.

Cite This Study

Soares et al. (2017) studied this question.

synapsesocial.com/papers/6a711d145d37378ac1de4656 https://doi.org/10.1155/2017/5038602

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Obesity Induces Artery-Specific Alterations: Evaluation of Vascular Function and Inflammatory and Smooth Muscle Phenotypic Markers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Obesity Induces Artery-Specific Alterations: Evaluation of Vascular Function and Inflammatory and Smooth Muscle Phenotypic Markers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider