Why the study?
Does sodium dantrolene reduce elevated intracellular calcium in a rat model of sepsis?
Population
Rat thoracic aorta (intact perfused organ) in a sepsis model
Comparison
Sodium dantrolene vs Sepsis without dantrolene / control values
Design
Preclinical
Authors
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No change to clinical sepsis care; leaves open dantrolene for calcium-targeted research in models.
Does sodium dantrolene reduce elevated intracellular calcium in a rat model of sepsis?
Sodium dantrolene reduces sepsis-induced elevations in intracellular calcium in rat aortic smooth muscle, highlighting a potential therapeutic target for sepsis.
Song et al. (1993) studied this question.
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