January 1, 2001Shock

Calcium Uptake by Sarcoplasmic Reticulum Is Impaired During the Hypodynamic Phase of Sepsis in the Rat Heart

View Full Paper

Ask AI

Bookmark

Population

Rat model of sepsis induced by cecal ligation and puncture (CLP)

Comparison

Sepsis vs Sham-operated control rats

Design

Preclinical

Authors

LWLi‐Ling WuNorth Sichuan Medical University YJYong JiNingbo University LDLin-Wang DongPeking University

Discussion

Member takes

Implication

May implicate defective SR Ca2+ uptake in late septic cardiomyopathy; hypothesis-generating in animals, human relevance remains open.

Structured PICO

Population

Rat model of sepsis induced by cecal ligation and puncture (CLP)

Intervention

Sepsis (early hyperdynamic phase and late hypodynamic phase)

Comparator

Sham-operated control rats

Outcome

Rates of ATP-dependent Ca2+ uptake in the cardiac sarcoplasmic reticulum (SR)surrogate

Sepsis-induced cardiac dysfunction during the late hypodynamic phase may be driven by impaired ATP-dependent Ca2+ uptake in the sarcoplasmic reticulum due to defective protein phosphorylation.

Cite This Study

Wu et al. (2001) studied this question.

synapsesocial.com/papers/6a7b28a48d250a4360f45370 https://doi.org/10.1097/00024382-200115010-00008

View Full Paper

Ask AI

Bookmark

Calcium Uptake by Sarcoplasmic Reticulum Is Impaired During the Hypodynamic Phase of Sepsis in the Rat Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Calcium Uptake by Sarcoplasmic Reticulum Is Impaired During the Hypodynamic Phase of Sepsis in the Rat Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider