July 1, 2001Shock

Impairment of the Ryanodine-Sensitive Calcium Release Channels in the Cardiac Sarcoplasmic Reticulum and Its Underlying Mechanism During the Hypodynamic Phase of Sepsis

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Population

Rats with sepsis induced by cecal ligation and puncture (CLP)

Comparison

Sepsis progression vs Control rats

Design

Preclinical

Follow-up

18 hours

Authors

LDLin-Wang DongPeking University LWLi‐Ling WuNorth Sichuan Medical University YJYong Ji

Discussion

Member takes

Implication

Suggests late-phase SR Ca2+ defects in septic models; leaves open translation to human cardiomyopathy and therapies.

Structured PICO

Population

Rats with sepsis induced by cecal ligation and puncture (CLP)

Intervention

Sepsis progression (early phase at 9 h, late phase at 18 h after CLP)

Comparator

Control rats

Outcome

Ca2+-induced Ca2+ release from cardiac sarcoplasmic reticulum and [3H]ryanodine bindingsurrogate

Sepsis induces a late-phase impairment in cardiac sarcoplasmic reticulum Ca2+ release due to a quantitative reduction in Ca2+ release channels, likely mediated by membrane lipid profile modifications.

Cite This Study

Dong et al. (2001) studied this question.

synapsesocial.com/papers/6a7b28a48d250a4360f4536f https://doi.org/10.1097/00024382-200116010-00007

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Impairment of the Ryanodine-Sensitive Calcium Release Channels in the Cardiac Sarcoplasmic Reticulum and Its Underlying Mechanism During the Hypodynamic Phase of Sepsis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Impairment of the Ryanodine-Sensitive Calcium Release Channels in the Cardiac Sarcoplasmic Reticulum and Its Underlying Mechanism During the Hypodynamic Phase of Sepsis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider