October 1, 1999Cardiovascular ResearchOpen Access

Abnormal Ca2+ release from cardiac sarcoplasmic reticulum in tachycardia-induced heart failure

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Why the study?

Does pacing-induced heart failure alter the Ca2+ release function of the sarcoplasmic reticulum in dog left ventricular muscles?

Population

Dog left ventricular (LV) muscles (normal, n = 10; pacing-induced heart failure, n = 10)

Comparison

Pacing-induced heart failure model vs Normal dog left ventricular muscles

Design

Preclinical

Authors

TYTakahiro YamamotoFukuoka Hospital

Discussion

Member takes

Implication

Impaired SR Ca2+ release in pacing-induced canine HF; hypothesis-generating for mechanisms in human disease.

Structured PICO

Does pacing-induced heart failure alter the Ca2+ release function of the sarcoplasmic reticulum in dog left ventricular muscles?

Population

Dog left ventricular (LV) muscles (normal, n = 10; pacing-induced heart failure, n = 10)

Intervention

Pacing-induced heart failure model

Comparator

Normal dog left ventricular muscles

Outcome

Ca2+ uptake and rapid kinetics of polylysine-induced Ca2+ release from cardiac sarcoplasmic reticulumsurrogate

In a dog model of pacing-induced heart failure, the Ca2+ releasing function of the sarcoplasmic reticulum is disturbed, characterized by reduced Ca2+ uptake and lower ryanodine receptor density.

Cite This Study

Takahiro Yamamoto (1999) studied this question.

synapsesocial.com/papers/6a7052bbac440176ef28fc87 https://doi.org/10.1016/s0008-6363(99)00200-x

Topics

Heart failure HFrEF treatment

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Abnormal Ca2+ release from cardiac sarcoplasmic reticulum in tachycardia-induced heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Abnormal Ca2+ release from cardiac sarcoplasmic reticulum in tachycardia-induced heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider