Population
Rabbit ventricular myocytes (from normal and failing hearts)
Comparison
Caffeine 250 microM vs Baseline (pre-caffeine) or non-failing myocytes
Design
Preclinical
Authors
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May enhance SR Ca2+ release in failing myocytes via ryanodine receptor sensitization; hypothesis-generating for human heart failure therapies.
Altering the termination level for local Ca2+ release via ryanodine receptor sensitization may represent a novel mechanism to increase SR Ca2+ release and contractility during excitation-contraction coupling in heart failure.
Domeier et al. (2009) studied this question.
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