Why the study?
Does cardiomyocyte-specific upregulation of MEK1-ERK1/2 signaling prevent chronic post-myocardial infarction remodeling in mice?
Population
Mice undergoing permanent coronary ligation (myocardial infarction model)
Comparison
Cardiomyocyte-specific upregulation of the… vs Wildtype (WT) controls
Design
Preclinical
Follow-up
4 weeks
Authors
Loading...
Hypothesis-generating for MEK1-ERK1/2 in post-MI remodeling; prospective studies needed before clinical translation.
Does cardiomyocyte-specific upregulation of MEK1-ERK1/2 signaling prevent chronic post-myocardial infarction remodeling in mice?
Cardiomyocyte-specific activation of MEK1-ERK1/2 signaling preserves left ventricular function and reduces pathological remodeling during the chronic post-myocardial infarction period in mice.
Yeh et al. (2012) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: