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March 1, 2007Cardiovascular ResearchOpen Access

Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3)

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Why the study?

Does MKK3 deletion prevent left ventricular remodeling following myocardial infarction in mice?

Population

Male MKK3-null mice and wild-type littermates subjected to permanent coronary artery ligation

Comparison

MKK3 gene knockout (mkk3-/-) vs Wild-type littermates (mkk3+/+)

Design

Preclinical

Follow-up

28 days

Authors

JCJames ClarkRFRichard A. FlavellMFMatthew Faircloth

Discussion

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Overview

MKK3 deletion does not mitigate post-MI LV remodeling in mice; leaves open its relevance as a therapeutic target in human HF.

Structured PICO

Does MKK3 deletion prevent left ventricular remodeling following myocardial infarction in mice?

P
Population
Male MKK3-null (mkk3-/-) mice and wild-type (mkk3+/+) littermates subjected to permanent coronary artery ligation
I
Intervention
MKK3 gene knockout (mkk3-/-)
C
Comparator
Wild-type littermates (mkk3+/+)
O
Outcome
Left ventricular remodeling (assessed by haemodynamics using a pressure-conductance catheter and morphometric analysis) at 28 days post-MIsurrogate

MKK3 is not essential for left ventricular remodeling following myocardial infarction, as pathological changes continue in its absence.

Cite This Study

Clark et al. (2007) studied this question.

synapsesocial.com/papers/6a86a10e3e22360d2d0cfc40https://doi.org/10.1016/j.cardiores.2007.02.027
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