Why the study?
Does local adenovirus-mediated cotransfection of WT p38 kinase and constitutively active MKK3b improve left ventricular remodeling in rats after myocardial infarction?
Population
Rats subjected to myocardial infarction by ligating the left anterior descending coronary artery
Comparison
Local adenovirus-mediated cotransfection of… vs LacZ-treated control
Design
Preclinical
Authors
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Hypothesis-generating for p38 kinase gene transfer in post-MI remodeling; human translation untested and requires prospective validation.
Does local adenovirus-mediated cotransfection of WT p38 kinase and constitutively active MKK3b improve left ventricular remodeling in rats after myocardial infarction?
Gene transfer of p38 kinase rescues failing myocardium by reducing infarct size, apoptosis, and fibrosis while increasing capillary density in a rat model of myocardial infarction.
Tenhunen et al. (2006) studied this question.
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