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May 27, 2022Nature CommunicationsOpen Access

Activation of Nkx2.5 transcriptional program is required for adult myocardial repair

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Why the study?

The embryonic cardiac developmental signals triggered following myocardial injury have yet to be fully elucidated.

Population

Adult nkx2.5 -/- fish

Comparison

Ventricular apex amputation in nkx2.5 -/- fish vs controls

Design

Preclinical animal study

Authors

CSCarmen de Sena-TomásUniversitat de BarcelonaAAAngelika G. AlemanPediatric / Congenital CardiologyCFCaitlin FordColumbia University

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Implication

Disrupted post-injury embryonic profile may limit regeneration; leaves open whether Nkx2.5 modulation enhances repair.

Structured PICO

P
Population
Adult teleost heart model (zebrafish) with Nkx2.5 loss-of-function (nkx2.5 -/-)
I
Intervention
Ventricular apex amputation in Nkx2.5 loss-of-function model
C
Comparator
Wild-type/control model (implied)
O
Outcome
Myocardial recovery, dedifferentiation, and proliferation following ventricular apex amputationsurrogate

Nkx2.5 is essential for adult myocardial regeneration, driving a transcriptional program that enables cardiomyocyte dedifferentiation and proliferation after injury.

Cite This Study

Sena-Tomás et al. (2022) studied this question.

synapsesocial.com/papers/6a711da078a11c550e0b2a41https://doi.org/10.1038/s41467-022-30468-4
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