Why the study?
Does physiologic tachycardia and dobutamine loading increase the occurrence of mechanical and electrical alternans in patients with chronic heart failure?
Population
94 patients with chronic heart failure, mean LVEF 35 +/- 10%
Comparison
Physiologic tachycardia and stepwise dobutamine… vs Rest
Design
Cross-sectional
Authors
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Dobutamine increases alternans prevalence in chronic HF; hypothesis-generating for TWA as LVEF marker, needs prospective validation.
Does physiologic tachycardia and dobutamine loading increase the occurrence of mechanical and electrical alternans in patients with chronic heart failure?
Visible T wave alternans is detectable in chronic heart failure patients, especially under tachycardia or catecholamine exposure, and is linked to mechanical alternans and lower LVEF.
Kodama et al. (2004) studied this question.
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