Impact of multimorbidity on long-term outcomes in older adults with non-ST elevation acute coronary syndrome in the North East of England: a multi-centre cohort study of patients undergoing invasive care
Why the study?
Older adults have a higher degree of multimorbidity, which may adversely affect longer term outcomes from non-ST elevation acute coronary syndrome.
Does higher multimorbidity increase the risk of adverse cardiovascular events in older adults with NSTE-ACS referred for coronary angiography?
Population
298 patients aged ≥75 years with NSTE-ACS referred for coronary angiography
Comparison
Higher CCI score (≥6) vs few comorbidities (CCI score 3-5)
Design
Multicentre prospective cohort study
Follow-up
5 years
Authors
Discussion
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Member takes
Implication
Multimorbidity was associated with higher long-term risk in older NSTE-ACS patients after invasive care; leaves open whether comorbidity-targeted strategies improve outcomes.
Structured PICO
Does higher multimorbidity increase the risk of adverse cardiovascular events in older adults with NSTE-ACS referred for coronary angiography?
P
Population
298 older adults (aged ≥75 years) with non-ST elevation acute coronary syndrome (NSTE-ACS) referred for coronary angiography, mean age 80.9 years. Multicentre cohort in the North East of England.
I
Intervention
Higher multimorbidity (Charlson comorbidity index [CCI] score ≥6)
C
Comparator
Lower multimorbidity (Charlson comorbidity index [CCI] score 3-5)
O
Outcome
Composite of all-cause mortality, myocardial infarction, stroke, urgent repeat revascularisation or significant bleeding at 5 yearscomposite
In older adults (≥75 years) with NSTE-ACS undergoing invasive care, a higher burden of multimorbidity significantly increases the 5-year risk of adverse cardiovascular events and mortality.
Cite This Study
Beska et al. (2022) studied this question.