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employed to determine the site of infection, indicate that recurrent infection may not necessarily involve the upper tract and offer an explanation of why only some patients with chronic bacteriuria are unable to excrete a maximally concentrated urine [6, 7]. The present study was undertaken to compare the maximal urinary concentrating ability in patients with infection carefully localized to the bladder with patients in whom bacteriuria emanated from 1 or both upper collecting systems. In addition, the infected kidney and its noninfected counterpart were compared during maximal antidiuresis in patients with unilateral infection. Finally, patients with impaired function on the initial examination were reevaluated following antimicrobial therapy.
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Clark et al. (1969) studied this question.
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