May 1, 2000The Journal of Clinical Endocrinology & MetabolismOpen Access

Estrogens Exert Route- and Dose-Dependent Effects on Insulin-Like Growth Factor (IGF)-Binding Protein-3 and the Acid-Labile Subunit of the IGF Ternary Complex*

View Full Paper

Ask AI

Bookmark

Why the study?

Do exogenous estrogens alter serum levels of IGFBP-3 and ALS in postmenopausal and hypogonadal GH-deficient women?

Structured PICO

Do exogenous estrogens alter serum levels of IGFBP-3 and ALS in postmenopausal and hypogonadal GH-deficient women?

Population

Normal postmenopausal women and hypogonadal GH-deficient women

Intervention

Exogenous estrogens (oral and transdermal, various formulations including ethinyl estradiol, conjugated estrogen, and estradiol valerate, and various dosages)

Comparator

Transdermal estrogen, different oral formulations, and different dosages

Outcome

Serum levels of IGF-binding protein-3 (IGFBP-3) and the acid-labile subunit (ALS)surrogate

Exogenous oral estrogens suppress serum IGFBP-3 and ALS in a route- and dose-dependent manner, independent of endogenous GH status.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Oral estrogen may confound IGFBP-3/ALS interpretation; leaves open relevance for GH dosing in deficient women.

Cite This Study

Kam et al. (2000) studied this question.

synapsesocial.com/papers/6a7120c2e71d69abee090dfa https://doi.org/10.1210/jcem.85.5.6527

View Full Paper

Ask AI

Bookmark

Estrogens Exert Route- and Dose-Dependent Effects on Insulin-Like Growth Factor (IGF)-Binding Protein-3 and the Acid-Labile Subunit of the IGF Ternary Complex*

Structured PICO

Discussion

Implication

Cite This Study

Estrogens Exert Route- and Dose-Dependent Effects on Insulin-Like Growth Factor (IGF)-Binding Protein-3 and the Acid-Labile Subunit of the IGF Ternary Complex*

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider