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January 31, 2023Frontiers in PharmacologyOpen Access

L-carnitine intervention ameliorated hyperuricemia-associated left ventricular anterior wall thickening in mice and attenuated cytoplasmic lipid deposition.

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Why the study?

Hyperuricemia is associated with left ventricular remodeling, but its effect on cardiomyocytic fatty acid metabolism remains unclear.

Does L-carnitine attenuate hyperuricemia-associated left ventricular remodeling in mice?

Population

Mice with HUA and UA-treated cardiomyocytes

Comparison

L-carnitine intervention vs control

Design

Preclinical animal and cellular study

Authors

YYYang YangCLCuiting LinQZQiang Zheng

Discussion

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Overview

No immediate clinical implications for hyperuricemia management; leaves open mechanistic role of fatty acid metabolism in remodeling.

Structured PICO

Does L-carnitine attenuate hyperuricemia-associated left ventricular remodeling in mice?

P
Population
Mice with hyperuricemia (HUA) and cardiomyocytes with uric acid (UA)-induced injury
I
Intervention
L-carnitine (LC)
O
Outcome
Left ventricular anterior wall thickening and cardiomyocytic lipid depositionsurrogate

L-carnitine attenuates hyperuricemia-induced left ventricular remodeling by promoting fatty acid transport and reducing cardiomyocytic lipid deposition in preclinical models.

Cite This Study

Yang et al. (2023) studied this question.

synapsesocial.com/papers/6a712464c2d7c3090827044fhttps://doi.org/10.3389/fphar.2023.1016633
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