Why the study?
Does therapeutic plasma exchange prevent complications in a pregnant woman with severe primary hypertriglyceridemia?
Does therapeutic plasma exchange prevent complications in a pregnant woman with severe primary hypertriglyceridemia?
Therapeutic plasma exchange and plasmapheresis can be safely and effectively used to manage severe primary hypertriglyceridemia during pregnancy.
Plasma exchange may manage severe gestational hypertriglyceridemia; leaves open need for prospective safety and efficacy trials.
The increase in plasma triglyceride level in pregnancy is modest, but in those who have deficiencies in lipoprotein lipase or apolipoprotein C-II (i.e., familial hyperlipidemia), the increase in very LDL concentration cannot be controlled and results in severe hypertriglyceridemia. This case is related to severe primary hypertriglyceridemia (types V) detected on the 25th week of gestation and treated with regular therapeutic plasma exchange and later on with alternate plasmapheresis with donated plasma. No complications were observed. A healthy male baby was delivered on the 39th week of pregnancy. After giving birth, the maternal triglyceride levels showed a remarkable reduction.
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Dženkevičiūtė et al. (2015) studied this question.
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