February 1, 1993Clinical Science

Intracellular pH regulation in isolated myocytes from adult rat heart in HCO-3-containing and HCO-3-free media

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Population

Isolated adult rat ventricular myocytes

Comparison

Exposure to HCO3-containing media and inhibitors vs HCO3(-)-free media

Design

Preclinical

Authors

LNLeong L. NgHeart Failure & Transplant JDJoan E. DaviesUniversity of Leicester PQP. QuinnUniversity of Leicester

Discussion

Member takes

Implication

Hypothesis-generating for cardiomyocyte pH recovery pathways; leaves open translation to human cardiac function or therapy.

Structured PICO

Population

Isolated adult rat ventricular myocytes

Intervention

Exposure to HCO3(-)-containing media and inhibitors (ethylisopropyl amiloride, 4,4'-di-isothiocyanatostilbene-2,2'-disulphonate)

Comparator

HCO3(-)-free media

Outcome

Intracellular pH, buffering capacity, and intracellular pH recovery from intracellular acidosissurrogate

This study demonstrates that in adult rat ventricular myocytes, recovery from intracellular acidosis involves both Na+/H+ antiport activity and a Na(+)-dependent, HCO3(-)-dependent H+ efflux mechanism.

Cite This Study

Ng et al. (1993) studied this question.

synapsesocial.com/papers/6a7127faac440176ef29d6d0 https://doi.org/10.1042/cs0840133

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Intracellular pH regulation in isolated myocytes from adult rat heart in HCO-3-containing and HCO-3-free media

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Intracellular pH regulation in isolated myocytes from adult rat heart in HCO-3-containing and HCO-3-free media

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider