October 1, 1998The Journal of PhysiologyOpen Access

Evidence for an electrogenic Na+‐HCO3− symport in rat cardiac myocytes

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Population

Isolated rat ventricular myocytes

Comparison

Exposure to HCO3- buffer, anion blockers, or… vs Hepes buffer, absence of HCO3-, or absence of…

Design

Preclinical

Authors

EAErnesto A. AielloCentro de Investigaciones Cardiovasculares MPMartín Vila PetroffCentro de Investigaciones Cardiovasculares AMAlicia MattiazziConsejo Nacional de Investigaciones Científicas y Técnicas

Discussion

Member takes

Implication

Does not alter clinical arrhythmia management; leaves open electrogenic NBC role in human ventricular electrophysiology.

Structured PICO

Population

Isolated rat ventricular myocytes

Intervention

Exposure to HCO3- buffer, anion blockers (SITS, DIDS), or depolarizing membrane potential with 45 mM extracellular K+

Comparator

Hepes buffer, absence of HCO3-, or absence of extracellular Na+

Outcome

Electrogenicity of the Na+-HCO3- cotransport (measured via resting membrane potential, action potential duration, steady-state currents, and intracellular pH)surrogate

The study demonstrates that the cardiac Na+-HCO3- cotransport is electrogenic and significantly influences the resting membrane potential and action potential duration in rat ventricular myocytes.

Cite This Study

Aiello et al. (1998) studied this question.

synapsesocial.com/papers/6a7aa30a06bbdce361021f35 https://doi.org/10.1111/j.1469-7793.1998.137bf.x

View Full Paper

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Bookmark

Evidence for an electrogenic Na+‐HCO3− symport in rat cardiac myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence for an electrogenic Na+‐HCO3− symport in rat cardiac myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider