October 1, 1996Circulation Research

Role of an Electrogenic Na + -HCO 3 − Cotransport in Determining Myocardial pH i After an Increase in Heart Rate

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Population

Cat papillary muscles loaded with BCECF-AM

Comparison

Stepwise increments in the frequency of… vs Bicarbonate-free medium and pretreatment with SITS

Design

Preclinical

Authors

MHMarı́a C. Camilión de HurtadoBoehringer Ingelheim (Germany)BÁBernardo V. ÁlvarezConsejo Nacional de Investigaciones Científicas y Técnicas NPNéstor G. PérezApple (Israel)

Discussion

Member takes

Implication

Suggests protective Na+-HCO3- cotransport during tachycardia in myocytes; hypothesis-generating for in vivo pH regulation, requires translation studies.

Structured PICO

Population

Cat papillary muscles loaded with BCECF-AM

Intervention

Stepwise increments in the frequency of contraction from 15 to 100 bpm in CO2/HCO3(-)-buffered medium

Comparator

Bicarbonate-free (HEPES) medium and pretreatment with SITS (0.1 mmol/L)

Outcome

Intracellular pH (pHi)surrogate

Membrane depolarization during cardiac action potentials increases electrogenic Na+-HCO3- cotransport, allowing myocardial cells to recover from enhanced proton production during increased heart rates.

Cite This Study

Hurtado et al. (1996) studied this question.

synapsesocial.com/papers/6a7c207124f98b6d3fc2b79e https://doi.org/10.1161/01.res.79.4.698

View Full Paper

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Implication

Suggests protective Na+-HCO3- cotransport during tachycardia in myocytes; hypothesis-generating for in vivo pH regulation, requires translation studies.

Role of an Electrogenic Na + -HCO 3 − Cotransport in Determining Myocardial pH i After an Increase in Heart Rate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of an Electrogenic Na + -HCO 3 − Cotransport in Determining Myocardial pH i After an Increase in Heart Rate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider