Key result
Electrogenic Na+-HCO3- cotransport in ventricular myocytes displays functional variation among species, with outward currents of +0.52, +0.26, and +0.10 pA/pF in rat, guinea pig, and rabbit.
Population
Isolated ventricular myocytes from rat, rabbit, and guinea pig
Design
Preclinical
Authors
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Species variation in cardiac NBCe activity observed in vitro; leaves open relevance to human acid-base handling and ischemia therapies.
Electrogenic Na+-HCO3- cotransport in ventricular myocytes displays significant functional variation among rats, guinea pigs, and rabbits, and may coexist with electroneutral NBC activity.
Yamamoto et al. (2004) studied Isolated ventricular myocytes. Voltage-clamp and epifluorescence techniques was evaluated on NBC-mediated outward current at resting pHi. Electrogenic Na+-HCO3- cotransport in ventricular myocytes displays functional variation among species, with outward currents of +0.52, +0.26, and +0.10 pA/pF in rat, guinea pig, and rabbit.
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