Key result
Antibodies against NBCe1 extracellular loops had opposing effects on transporter function in cat ventricular myocytes, with a-L3 inhibiting and a-L4 stimulating pH(i) recovery.
Why the study?
Do antibodies against NBCe1 alter intracellular pH and transport activity in cat ventricular myocytes?
Do antibodies against NBCe1 alter intracellular pH and transport activity in cat ventricular myocytes?
Antibodies targeting different extracellular loops of NBCe1 have opposing functional effects (inhibitory vs excitatory) on intracellular pH regulation in cardiac myocytes, suggesting potential as pharmacological tools.
No takes yet. Share an insight, caveat, or question.
May enable selective NBCe1 modulation in cardiac myocytes; leaves open translation to human physiology or therapy.
Giusti et al. (2011) studied this question. Antibodies against putative extracellular loop domains 3 (a-L3) and 4 (a-L4) of NBCe1 vs. Control was evaluated on pH(i) increase during potassium pulse. Antibodies against NBCe1 extracellular loops had opposing effects on transporter function in cat ventricular myocytes, with a-L3 inhibiting and a-L4 stimulating pH(i) recovery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: