June 2, 2016ChannelsOpen Access

The cardiac electrogenic sodium/bicarbonate cotransporter (NBCe1) is activated by aldosterone through the G protein-coupled receptor 30 (GPR 30)

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Population

Adult rat ventricular myocytes

Design

Preclinical

Authors

AOAlejandro OrlowskiCentro de Investigaciones Cardiovasculares VGVerónica Celeste De GiustiCentro de Investigaciones Cardiovasculares MCMaría C. CiancioCentro de Investigaciones Cardiovasculares

Discussion

Member takes

Implication

Does not alter HF management; extends basic understanding of aldosterone-GPR30-NBC signaling in cardiomyocytes.

Structured PICO

Population

Adult rat ventricular myocytes

Intervention

Aldosterone (Ald) and specific NBCe1 inhibitory antibodies (a-L3)

Outcome

NBC isoform activity (NBCe1 vs NBCn1) and localizationsurrogate

Aldosterone specifically activates the electrogenic NBCe1 isoform in adult rat ventricular myocytes, with both NBCe1 and GPR30 localized in t-tubules.

Cite This Study

Orlowski et al. (2016) studied this question.

synapsesocial.com/papers/6a714cc335aa2c282ce29b9a https://doi.org/10.1080/19336950.2016.1195533

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The cardiac electrogenic sodium/bicarbonate cotransporter (NBCe1) is activated by aldosterone through the G protein-coupled receptor 30 (GPR 30)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The cardiac electrogenic sodium/bicarbonate cotransporter (NBCe1) is activated by aldosterone through the G protein-coupled receptor 30 (GPR 30)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider