Why the study?
Does ARNI improve cardiac and kidney parameters compared with ARB alone in diabetic TGR(mREN2)27 rats?
Does ARNI improve cardiac and kidney parameters compared with ARB alone in diabetic TGR(mREN2)27 rats?
In a diabetic rat model of hypertension, ARNI provided greater renoprotection and reduction in heart weight compared to ARB alone, independent of blood pressure lowering.
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Hypothesis-generating for ARNI in diabetic hypertensive models; leaves open clinical translation to heart failure.
Roksnoer et al. (2016) studied this question.
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