Altered megakaryocyte–platelet haemostatic axis in hypercholesterolaemia

22 subjects, including 8 untreated patients with primary hypercholesterolaemia (total cholesterol > 7 mmol/l) and 14 control subjects (total cholesterol <= 7 mmol/l).

Control subjects with total cholesterol <= 7 mmol/l

Megakaryocyte (MK) ploidy, size, granularity, and expression of GP IIIa, and platelet expression of GP IIIa, P selectin and CD 63, RNA content, mean platelet volume, platelet count, plasma thrombopoietin, and cutaneous bleeding timesurrogate