Why the study?
Does abnormal plasma lipoprotein composition from hypercholesterolaemic patients increase platelet activation compared to normal lipoproteins?
Population
11 male patients with familial hypercholesterolaemia and 10 age-matched healthy controls (n=21)
Comparison
In vitro incubation of normal platelets with… vs In vitro incubation of normal platelets with…
Design
Case-control
Authors
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May enhance platelet reactivity in hypercholesterolaemia; hypothesis-generating for mechanistic thrombotic risk links.
Does abnormal plasma lipoprotein composition from hypercholesterolaemic patients increase platelet activation compared to normal lipoproteins?
Abnormal lipid and protein composition of lipoproteins in familial hypercholesterolaemia induces platelet hyperactivity, providing a mechanistic link to increased cardiovascular risk.
Viener et al. (1984) studied this question.
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