Why the study?
Does myocardial infarction alter the gene expression of natriuretic peptides and their receptors in rats?
Population
Rats with induced myocardial infarction
Design
Preclinical
Follow-up
Up to 28 days post-MI
Authors
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Post-MI natriuretic peptide elevation in rats may involve upregulated cardiac expression and downregulated peripheral clearance; leaves open human relevance.
Does myocardial infarction alter the gene expression of natriuretic peptides and their receptors in rats?
Increased circulating natriuretic peptides post-MI in rats may be driven by both increased myocardial secretion and reduced peripheral clearance via NPR-C.
E. Øie M. E. Hystad (2001) studied this question.
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