Why the study?
The study aimed to evaluate the relationship between LVEF, LDL, BNP, Troponin I, and CFR, and to determine predictors of LVEF in patients with coronary microvascular disease with or without obstructive coronary artery disease.
Biomarkers including LDL-c, BNP, and Troponin-I, as well as coronary flow reserve, are significantly associated with left ventricular ejection fraction in patients with coronary microvascular and obstructive coronary artery disease.
Associations between biomarkers and LVEF in CMD are hypothesis-generating; leaves open whether they predict outcomes or guide therapy.
OBJECTIVE: The aim of our research was to evaluate the relationship involving left ventricular ejection fraction, low density lipoprotein, B-type natriuretic peptide, Troponin I and coronary flow reserve, and to determine the predictors of left ventricular ejection fraction in patients with coronary microvascular disease and obstructive coronary artery disease, and in patients with coronary microvascular disease. RESULTS: The mean age was 58.5 ± 12.5 years. In patients with obstructive coronary disease and coronary microvascular disease we found low density lipoprotein-c had significant inverse relationship with left ventricular ejection fraction, left ventricular ejection fraction also had significant negative relationship with B-type natriuretic peptide, and Troponin-I. While a significant direct relationship turned out to be observed linking left ventricular ejection fraction with coronary flow reserve. Left ventricular ejection fraction had significant negative relationship with low density lipoprotein, and B-type natriuretic peptide in patients with obstructive coronary artery disease only. Age, blood pressure, lipid levels, red cell distribution width, glycated hemoglobin, symptoms, New York heart association classification, alcohol drinking, hypertension, diabetes mellitus, troponin levels and B-type natriuretic peptide were the predictors for left ventricular ejection fraction in coronary microvascular disease patients.
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Mayala et al. (2020) studied this question.
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