October 23, 2008AJP Renal PhysiologyOpen Access

Chronic ouabain treatment induces vasa recta endothelial dysfunction in the rat

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Population

Rat renal vasculature (descending vasa recta)

Comparison

Acute ouabain exposure and chronic ouabain… vs Control/untreated state

Design

Preclinical

Follow-up

5 weeks

Authors

CCChunhua CaoShanghai Jiao Tong University KPKristie PayneUniversity of Maryland, Baltimore WLWhaseon Lee‐KwonUlsan National Institute of Science and Technology

Discussion

Member takes

Implication

Chronic ouabain impairs endothelial calcium signaling in rat vasa recta; hypothesis-generating for hypertension mechanisms, requires human validation.

Structured PICO

Population

Rat renal vasculature (descending vasa recta)

Intervention

Acute ouabain exposure (100 nM, 500 nM, or 1 mM) and chronic ouabain treatment (30 microg/kg/day for 5 weeks)

Comparator

Control/untreated state

Outcome

Endothelial cytoplasmic Ca(2+) ([Ca(2+)](CYT)) signaling and nitric oxide generation in descending vasa rectasurrogate

Chronic ouabain exposure in rats induces hypertension and descending vasa recta endothelial dysfunction, impairing calcium signaling responses to vasodilators.

Cite This Study

Cao et al. (2008) studied this question.

synapsesocial.com/papers/6a712ca435aa2c282ce27d10 https://doi.org/10.1152/ajprenal.90429.2008

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Implication

Chronic ouabain impairs endothelial calcium signaling in rat vasa recta; hypothesis-generating for hypertension mechanisms, requires human validation.

Chronic ouabain treatment induces vasa recta endothelial dysfunction in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Chronic ouabain treatment induces vasa recta endothelial dysfunction in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider