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April 1, 1989Journal of VirologyOpen Access

Sindbis virus mutations which coordinately affect glycoprotein processing, penetration, and virulence in mice

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Population

Baby hamster kidney cells and mice (adult and neonatal)

Comparison

Sindbis virus S.A.AR86 strain pathogenesis mutants vs Parent virus (S.A.AR86 strain)

Design

Preclinical

Authors

DRDarcy L. RussellBaker UniversityJDJoel M. DalrympleRutgers, The State University of New JerseyRJRowena JohnstonAmerican Foundation for AIDS Research

Discussion

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Implication

Informs alphavirus attenuation mechanisms in mice; leaves open relevance to human pathogenesis or vaccines.

Structured PICO

P
Population
Baby hamster kidney cells and mice (adult and neonatal)
I
Intervention
Sindbis virus S.A.AR86 strain pathogenesis mutants (selected for rapid penetration)
C
Comparator
Parent virus (S.A.AR86 strain)
O
Outcome
Virulence/attenuation in mice, glycoprotein processing, and sequence analysissurrogate

Specific point mutations in the E2 glycoprotein of Sindbis virus S.A.AR86 strain coordinately affect viral penetration, glycoprotein processing, and virulence in mice.

Cite This Study

Russell et al. (1989) studied this question.

synapsesocial.com/papers/6a712ff4ac440176ef29de7dhttps://doi.org/10.1128/jvi.63.4.1619-1629.1989
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