Why the study?
Does mutation of Sindbis virus alter its virulence and lethality in neonatal mice?
Population
Neonatal mice
Comparison
Intracerebral injection of temperature-sensitive… vs Comparison between different ts mutants
Design
Preclinical
Follow-up
Up to 7 days
Authors
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RNA phenotype and reversion shape Sindbis lethality in neonatal mice; leaves open generalization to other hosts or viruses.
Does mutation of Sindbis virus alter its virulence and lethality in neonatal mice?
The virulence of Sindbis virus in neonatal mice can be significantly altered by temperature-sensitive mutations, which correlates with events at the cellular level such as RNA phenotype and reversion rates.
Barrett et al. (1979) studied this question.
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