Population
BHK-21 cells infected at 39 degrees C
Comparison
Infection with 12 temperature-sensitive mutants… vs Wild-type virus (for interference assessment)
Design
Preclinical
Follow-up
beyond the fifth cell passage post-infection
Authors
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Hypothesis-generating for Sindbis ts mutant persistence mechanisms in vitro; leaves open in vivo or clinical relevance.
In BHK-21 cells, persistent infection by Sindbis virus ts mutants depends on early inhibition of virus multiplication and occurs in a small proportion of cells.
Gerald J. Atkins (1979) studied this question.
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