Key result
Defective-interfering Sindbis virus induces interferon at 30 degrees C but not at 40.5 degrees C.
This study demonstrates for the first time that a defective-interfering particle possesses a temperature-sensitive function for interferon induction, suggesting its RNA genome can be translated to produce a dsRNA inducer.
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Sindbis DI particles show temperature-dependent interferon induction in vitro; leaves open in vivo relevance and therapeutic translation.
Fuller et al. (1980) studied this question. Defective-interfering (DI) particle of Sindbis virus (ts mutant) vs. Non-permissive temperature (40.5 degrees C) was evaluated on Interferon induction. A defective-interfering particle of Sindbis virus induced interferon at a permissive temperature (30 degrees C) but not at a non-permissive temperature (40.5 degrees C).
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