Induction of Interferon in Chick Cells by Temperature-sensitive Mutants of Sindbis Virus

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Population

Chick cells infected with 11 temperature-sensitive mutants of the HR strain, and 38 ts mutants of the AR339…

Comparison

Infection with ts mutants at varying… vs Wild-type Sindbis virus and varying temperature…

Design

Preclinical

Authors

Discussion

Does not yet inform clinical antiviral strategies; leaves open mechanistic relevance in mammalian systems.

Population

Chick cells infected with 11 temperature-sensitive (ts) mutants of the HR strain, and 38 ts mutants of the AR339 strain of Sindbis virus

Intervention

Infection with ts mutants at varying temperatures (30 °C, 39 °C, 42 °C), incubation times, and input multiplicities

Comparator

Wild-type Sindbis virus and varying temperature conditions

Outcome

Interferon induction and virus RNA synthesissurrogate

Interferon induction by Sindbis virus in chick cells depends on early viral RNA synthesis.

Atkins et al. (1974) studied this question.

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