December 1, 1999Journal of VirologyOpen Access

Infection of Neonatal Mice with Sindbis Virus Results in a Systemic Inflammatory Response Syndrome

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Population

Neonatal mice

Comparison

Infection with Sindbis virus strain TR339 vs Infection with cell culture-passaged laboratory…

Design

Preclinical

Authors

WKWilliam B. KlimstraUniversity of Pittsburgh KRKate D. RymanUniversity of North Carolina at Chapel Hill KBKristen A. BernardUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Findings in neonatal mice do not yet inform human care; extends understanding of viral attenuation mechanisms.

Structured PICO

Population

Neonatal mice

Intervention

Infection with Sindbis virus strain TR339 (consensus sequence of AR339 isolate)

Comparator

Infection with cell culture-passaged laboratory AR339 strain (TRSB) and a more highly cell culture-adapted strain, HR(sp) (Toto 50)

Outcome

Mortality and average survival time (AST)hard clinical

Cell culture-adaptive mutations in Sindbis virus attenuate its pathogenesis in neonatal mice, shifting the disease from a rapid systemic inflammatory response syndrome to a less lethal encephalitis.

Cite This Study

Klimstra et al. (1999) studied this question.

synapsesocial.com/papers/6a867545169aec2a7f0f77ad https://doi.org/10.1128/jvi.73.12.10387-10398.1999

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Infection of Neonatal Mice with Sindbis Virus Results in a Systemic Inflammatory Response Syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Infection of Neonatal Mice with Sindbis Virus Results in a Systemic Inflammatory Response Syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider