Population
Neonatal mice and cultured cells
Comparison
Recombinant large-plaque Sindbis virus mutants… vs Parental small-plaque Toto 1101 strain of…
Design
Preclinical
Authors
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Heparan sulfate binding may modulate alphavirus clearance and virulence in mice; leaves open relevance to human disease or interventions.
Decreased ability of Sindbis virus to bind to heparan sulfate leads to slower viral clearance, higher viremia, and increased mortality in vivo.
Byrnes et al. (2000) studied this question.
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