Population
Embryonated eggs (immunologically underdeveloped host) and chicks
Comparison
Infection with temperature-sensitive mutants of… vs Infection with parent Sindbis virus
Design
Preclinical
Authors
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Enables temperature-controlled pathogenesis studies in animal hosts; extends experimental tools but leaves open human translation.
Temperature-sensitive mutants of Sindbis virus are attenuated at nonpermissive temperatures, making them valuable tools for analyzing viral pathogenesis and immunity in intact animal hosts.
Schluter et al. (1974) studied this question.
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