April 1, 1985Journal of VirologyOpen Access

Studies of defective interfering RNAs of Sindbis virus with and without tRNAAsp sequences at their 5' termini

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Population

Cultured cells infected with Sindbis virus generating defective interfering (DI) particles

Comparison

Sindbis virus DI RNAs with tRNAAsp sequences at… vs Sindbis virus DI RNAs without tRNAAsp sequences

Design

Preclinical

Authors

MTManuel TsiangGilead Sciences (United States)SMStephan S. MonroeCenters for Disease Control and Prevention SSSondra SchlesingerWashington University in St. Louis

Discussion

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Implication

Challenges tRNAAsp role in DI RNA selection; leaves open primary determinants in Sindbis replication.

Structured PICO

Population

Cultured cells infected with Sindbis virus generating defective interfering (DI) particles

Intervention

Sindbis virus DI RNAs with tRNAAsp sequences at their 5' termini

Comparator

Sindbis virus DI RNAs without tRNAAsp sequences (tRNAAsp-negative DIs)

Outcome

Evolution and competitive ability of DI RNAs

The presence of a tRNAAsp sequence at the 5' terminus of Sindbis virus DI RNAs does not primarily determine their competitive dominance during viral replication.

Cite This Study

Tsiang et al. (1985) studied this question.

synapsesocial.com/papers/6a702023f44fa9f079ddad6d https://doi.org/10.1128/jvi.54.1.38-44.1985

View Full Paper

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Studies of defective interfering RNAs of Sindbis virus with and without tRNAAsp sequences at their 5' termini

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Studies of defective interfering RNAs of Sindbis virus with and without tRNAAsp sequences at their 5' termini

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider