Deoxyribonucleoproteins and the tissue-specific restriction of the deoxyribonucleic acid in chromatin

Although histones appear necessary for the restriction of DNA (Bonner et al. 1968), their lack of tissue and species specificity point to the necessary presence of other factors in chromatin that are required for the highly organ-specific genetic restriction of the DNA. The present paper analyses the type of restriction of the DNA in native chromatin by analysing the type of restriction in hybrid chromatins composed of portions of the dissociated products of the chromatins from two different organs.