Population
Moloney murine leukemia-sarcoma complex [MSV (MLV)] virions
Comparison
Serial passage at low dilution vs Serial passage at high dilution
Design
Preclinical
Authors
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May affect retroviral propagation outcomes in lab models; leaves open relevance to human viral dynamics or vaccine production.
Serial passage of MSV (MLV) at low dilution leads to autointerference, characterized by decreased infectivity and the emergence of a smaller RNA component.
Bondurant et al. (1973) studied this question.
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