What question did this study set out to answer?

To identify and characterize complementary RNA species of murine sarcoma-leukemia virus (MSV-MLV) within chronically infected and transformed host cells.

December 1, 1969Proceedings of the National Academy of SciencesOpen Access

Complementary Nuclear Rna's of Murine Sarcoma-Leukemia Virus Complex in Transformed Cells

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Authors

NBNilambar BiswalUniversity of Maryland, Baltimore MBMatilda Benyésh-MelnickWorld Health Organization - Pakistan

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Implication

Indicates viral-host RNA complementarity in transformed cells; leaves open retroviral integration mechanisms for further study.

Key Points

To identify and characterize complementary RNA species of murine sarcoma-leukemia virus (MSV-MLV) within chronically infected and transformed host cells.
Dissociated high molecular weight MSV-MLV viral RNA (69S) into 37S subunits by heat treatment at 95 degrees C for 2 minutes.
Conducted molecular annealing hybridization tests between viral RNA and RNA isolated from nuclear and cytoplasmic compartments of transformed 78 A1 cells.
Viral RNA hybridized specifically with two distinct nuclear RNA species displaying sedimentation coefficients of 31–36S and 18–22S.
No detectable annealing occurred between the viral RNA and host cytoplasmic RNA fractions.

Cite This Study

Biswal et al. (1969) studied this question.

synapsesocial.com/papers/6a901fdc02529ca22a278406 https://doi.org/10.1073/pnas.64.4.1372

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Complementary Nuclear Rna's of Murine Sarcoma-Leukemia Virus Complex in Transformed Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Complementary Nuclear Rna's of Murine Sarcoma-Leukemia Virus Complex in Transformed Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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