What question did this study set out to answer?

To examine the central role of intrarenal renin-angiotensin system activation in hypertension and describe the counteracting paracrine, endothelial, and neural mechanisms that modulate renal function.

February 28, 2007Acta Physiologica Hungarica

Intrarenal renin-angiotensin system and counteracting protective mechanisms in angiotensin II-dependent hypertension

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Authors

KMKenneth D. MitchellBio-Rad (United States)FBFady T. BotrosEli Lilly (United States)LNL. Gabriel NavarVascular Medicine

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Implication

Supports RAS blockade in hypertension; leaves open optimal intrarenal targeting for trials.

Key Points

To examine the central role of intrarenal renin-angiotensin system activation in hypertension and describe the counteracting paracrine, endothelial, and neural mechanisms that modulate renal function.
Narrative synthesis of pathophysiological mechanisms driving renal dysfunction and arterial pressure elevation.
Evaluation of interactions between intrarenal hormonal influences, extrarenal contributors, and counteracting endothelial and neural pathways.
Impairment of renal capacity to excrete sodium and regulate extracellular fluid volume represents a cardinal characteristic across all forms of hypertension.
Inappropriate activation of the renin-angiotensin system directly impairs renal handling of sodium, necessitating elevated arterial pressures to re-establish fluid balance.
Endogenous counteracting factors, including nitric oxide, carbon monoxide, arachidonic acid metabolites, and neural inputs, modulate and buffer against hypertensive actions.

Cite This Study

Mitchell et al. (2007) studied this question.

synapsesocial.com/papers/6a71368bf44fa9f079defd8a https://doi.org/10.1556/aphysiol.94.2007.1-2.5

Topics

Hypertension management

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Intrarenal renin-angiotensin system and counteracting protective mechanisms in angiotensin II-dependent hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

Topics

Intrarenal renin-angiotensin system and counteracting protective mechanisms in angiotensin II-dependent hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

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Topics

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