Atrioventricular Interval Optimization and Exercise Tolerance
Why the study?
Does rate adaptive AV interval shortening improve exercise capacity in patients with dual chamber pacemakers for AV block?
Population
14 patients with intact sinus node function and AV block treated with dual chamber pacemakers, mean age 64…
Comparison
Rate adaptive AV interval shortening vs Fixed AV interval of 150 ms without rate…
Design
RCT, randomized crossover, double-blind
Authors
Discussion
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Member takes
Implication
Supports rate-adaptive AV shortening to improve exercise capacity in dual-chamber paced AV block; extends evidence by showing fixed 150 ms equals optimization.
Structured PICO
Does rate adaptive AV interval shortening improve exercise capacity in patients with dual chamber pacemakers for AV block?
P
Population
14 patients with intact sinus node function and AV block treated with dual chamber pacemakers, mean age 64 +/- 8 years, 10 men and 4 women.
I
Intervention
Rate adaptive AV interval shortening (either optimized by Doppler echocardiography or fixed at 150 ms)
C
Comparator
Fixed AV interval of 150 ms without rate adaptation
O
Outcome
Exercise capacity determined by maximum oxygen uptake during serial graded exercise tests with spiroergometrysurrogate
Rate adaptive AV interval shortening improves exercise tolerance in patients with dual chamber pacemakers, but individual optimization with resting echocardiography provides no additional benefit over a fixed rate-adaptive interval.
Cite This Study
Khairy et al. (2001) studied this question.