October 9, 2006British Journal of PharmacologyOpen Access

A Rabbit Langendorff Heart Proarrhythmia Model: Predictive Value for Clinical Identification of Torsades de Pointes

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Population

Rabbit isolated Langendorff heart model (SCREENIT)

Comparison

55 marketed drugs or drugs intended for market vs 2 controls

Design

Preclinical, blinded manner

Authors

CLCaryn LawrenceUniversity of North Carolina at Chapel Hill MBM H Bridgland‐TaylorAstraZeneca (United Kingdom)CPC.E. PollardAstraZeneca (United Kingdom)

Discussion

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Implication

Supports 30-fold safety margin in rabbit proarrhythmia screening; leaves open human TdP translation pending clinical validation.

Structured PICO

Population

Rabbit isolated Langendorff heart model (SCREENIT)

Intervention

55 marketed drugs or drugs intended for market

Comparator

2 controls

Outcome

Proarrhythmic scores based on variables including 10% change in MAPD(60), triangulation, instability, reverse frequency-dependence of MAP, early after-depolarisations, ventricular tachycardia, TdP, and ventricular fibrillationsurrogate

The rabbit Langendorff heart model (SCREENIT) is a robust assay for predicting clinical Torsades de Pointes risk, with a 30-fold margin between effects and EFTPC(max) providing confidence for new chemical entities.

Cite This Study

Lawrence et al. (2006) studied this question.

synapsesocial.com/papers/6a7139528031ec7bb1dcd4e1 https://doi.org/10.1038/sj.bjp.0706894

View Full Paper

Ask AI

Bookmark

A Rabbit Langendorff Heart Proarrhythmia Model: Predictive Value for Clinical Identification of Torsades de Pointes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Rabbit Langendorff Heart Proarrhythmia Model: Predictive Value for Clinical Identification of Torsades de Pointes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider